Striatal Outflow of Adenosine, Excitatory Amino Acids, g-Aminobutyric Acid, and Taurine in Awake Freely Moving Rats After Middle Cerebral Artery Occlusion Correlations With Neurological Deficit and Histopathological Damage
نویسندگان
چکیده
Alessia Melani, Leonardo Pantoni, Claudia Corsi, Loria Bianchi, Angela Monopoli, Rosalia Correlations With Neurological Deficit and Histopathological Damage Taurine in Awake Freely Moving Rats After Middle Cerebral Artery Occlusion : -Aminobutyric Acid, and γ Striatal Outflow of Adenosine, Excitatory Amino Acids, Print ISSN: 0039-2499. Online ISSN: 1524-4628 Copyright © 1999 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231 Stroke doi: 10.1161/01.STR.30.11.2448 1999;30:2448-2455 Stroke. http://stroke.ahajournals.org/content/30/11/2448 World Wide Web at: The online version of this article, along with updated information and services, is located on the
منابع مشابه
Inhibition of excitatory amino acid efflux contributes to protective effects of puerarin against cerebral ischemia in rats.
OBJECTIVE To investigate whether the protective effects of puerarine (Pur) against cerebral ischemia is associated with depressing the extracellular levels of amino acid transmitters in brain of rats. METHODS Male Sprague-Dawley rats were subjected to transient middle cerebral artery occlusion (MCAO) for 60 min followed by 24 h reperfusion. Pur (50, 100 mg/kg, i.p.) was administered at the on...
متن کاملNeuroprotective effects of crocin on the histopathological alterations following brain ischemia-reperfusion injury in rat
Objective(s): Some histopathological alterations take place in the ischemic regions following brain ischemia. Recent studies have demonstrated some neuroprotective roles of crocin in different models of experimental cerebral ischemia. Here, we investigated the probable neuroprotective effects of crocin on the brain infarction and histopathological changes after transient model of focal cerebral...
متن کاملEffects of gastrodin on amino acids after cerebral ischemia-reperfusion injury in rat striatum.
The aim of this study was to explore the effect of gastrodin on the level of amino acids in the striatum in the rats of cerebral ischemia-reperfusion injury. 30 male SD rats were randomly divided into 3 groups: the group of pseudo-operation (normal control group, NC group), the group of cerebral ischemia-reperfusion injury (CIRI group), and the group of cerebral ischemia-reperfusion injury trea...
متن کاملEffect of Combination Therapy Using Hypothermia and Granulocyte Colony-Stimulating Factor in a Rat Transient Middle Cerebral Artery Occlusion Model
Background: Stroke is the third leading cause of death. Hypothermia has been recognized as an effective method in reducing brain injury. In this study, we assessed the effects of granulocyte colony-stimulating factor (G-CSF) as a neuroprotective agent and mild hypothermia on mortality, behavioral function, infarct volume, and brain edema in Wistar rats. Methods: Forty male rats were used in fiv...
متن کاملResearch Paper: Optimization of Transient Focal Cerebral Ischemia Model by Middle Cerebral Artery Occlusion
Introduction: Cerebral ischemia is one of the most common causes of death in human populations in the industrial communities. The need for animal models is inevitable to study the pathophysiology and treatment of cerebral ischemia in human. The current study aimed at evaluating the strengths and weaknesses of different techniques used to create ischemia in previous studies and optimizing the tr...
متن کامل